The clinical and pathologic features of these cases of sudden death, especially the characteristic lack of overt structural heart disease, are similar among cases. Autopsy findings in cases of SUNDS reveal no evident histopathological changes that explain the cause of death. Sudden unexplained nocturnal death syndrome (SUNDS) is a genetic disorder that can cause sudden death in young, healthy adults during sleep at night. Sudden death is a major concern in forensic medicine, especially when the decedent is young and healthy and the postmortem examination fails to reveal any significant findings. Two identified variants (rs1805126 and rs7429945) deserved further study because of their strong odd ratios. Twelve variants of SCN5A were identified, including six polymorphisms and another six variants previously reported to be related with cardiac conduction defects. The identified variants were also genotyped in control subjects using high-resolution melting analysis and sequencing. Genomic DNA from SUNDS cases was screened for genetic variations for the entire 28 coding exons of SCN5A. Subjects were divided into three subgroups as follows: subjects who resided in regions other than Northeastern Thailand ( n = 99), age-matched subjects who resided in Northeastern Thailand ( n = 28), and subjects older than 40 years who resided in Northeastern Thailand ( n = 24). Genomic DNA was extracted using blood samples from 12 unrelated SUNDS subjects and 151 unrelated non-SUNDS control decedents. This study was thus aimed to investigate the association between SCN5A, the gene that has been extensively studied and thought to be associated with cardiac conduction system abnormality causing sudden cardiac death, and SUNDS in Thai decedents. Cardiac arrhythmia has been proposed as the factor responsible for such deaths. Its contents and purpose may however evolve depending on the community.Sudden unexplained nocturnal death syndrome (SUNDS) is a genetic disorder that can cause sudden death in young and healthy adults during sleep at night. As of now this repository is used to keep track of the current mutation testing tools developed and related resources. Mutation testing is the practice of making better code by introducing bugs.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
January 2023
Categories |